"On some morbid appearances of the absorbent glands and spleen".; In: Medico-Chirurgical Transactions, Published by the Medical and Chirurgical Society

London: Longman, Rees, Orme, et al, 1832. First edition. 8vo. Hodgkin's paper is on pp. 68-114. Entire volume: xxiii, 523 pp. Original embossed cloth, gilt-lettered on spine, gilt crest on front cover. Chipping to ends of spine, library bookplate on pastedown, hinges cracked but volume tight and clean / From the Collection of Allan B. Kirsner, M.D. Item #401994

The first full description of lymphadenoma, now known as “Hodgkin’s disease”. Hodgkin’s historic paper was read before the society on 10 and 24 January 1832. With characteristic modesty, Hodgkin outlined his findings, showing his careful scholarly correlation of clinical medicine and morbid anatomy in the delineation of the disease. “The morbid alterations of structure which I am about to describe are probably familiar to many practical morbid anatomists, since they can scarcely have failed to have fallen under their observation in the course of cadaveric inspection. They have not, as far as I am aware, been made the subject of special attention, on which account I am induced to bring forward a few cases in which they have occurred to myself, trusting that I shall at least escape severe or general censure, even though a sentence or two should be produced from some existing work, couched in such concise but expressive language, as to render needless the longer details with which I shall trespass on the time of my hearers.” He was most likely correct that others had observed the same condition. David Craigie, for example, discusses the pathology of the lymphatic glands in his Elements of General and Pathological Anatomy (1828), citing repeated attacks of inflammation alternating with resolution. But it seems unlikely that Craigie recognized the distinctive nature of the disease process. Hodgkin, however, was convinced that he was dealing with a primary disease of the absorbent (lymphatic) glands and not a banal secondary response to an obscure inflammatory condition. He briefly describes six cases, and references a seventh seen by Carswell, and his conclusions correctly identified the disease that now bears his name. See Henry S. Kaplan, Hodgkin’s Disease, 2nd ed., Cambridge, 1980, p. 1ff. Garrison-Morton-Norman 3762. .

Price: $8,000.00

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